OASYS - Optoelectronic sensors for application-oriented systems for life sciences and intelligent manufacturing

High-Resolution Imaging for the Medicine of the Future

Light-based imaging techniques are among the most important tools in modern medicine. However, their performance is significantly limited when light encounters highly scattering materials such as biological tissue. Scattering, absorption, and reflection alter the propagation of light, substantially reducing both imaging depth and image quality.

In Subproject B1 of OASYS, Fraunhofer IPMS, at its Integrated Silicon Systems branch in Cottbus, is developing novel optical techniques to overcome these physical limitations. The goal is to investigate intelligent imaging systems capable of producing high-resolution, high-precision images even in deeper layers of biological tissue, thereby opening up new opportunities for diagnostics, medical research, and life science applications.

Research Approach

The core of this subproject is the development of MEMS-based Spatial Light Modulators (SLMs). These microelectromechanical systems consist of thousands to millions of individually addressable micromirrors. Their highly dynamic control enables precise manipulation of the wavefront of incident light, allowing optical distortions caused by scattering media to be actively compensated.

This enables adaptive wavefront correction, significantly improving image quality and making optical imaging possible in regions that have previously been difficult or impossible to access.

Project Objectives

The objective of this subproject is to develop innovative technologies for high-resolution optical imaging and make them available for future applications. The main focus areas include:

• Development of novel MEMS-based Spatial Light Modulators (SLMs)
• Adaptive correction of optical wavefronts in scattering media
• Enhancement of the spatial resolution and imaging depth of optical systems
• Development of compact and energy-efficient sensor systems
• Translation of research results into practical, real-world applications

Application Areas

The technologies developed in this subproject offer broad application potential across medicine, scientific research, and the high-tech industry.

Medical Diagnostics

Enhanced imaging enables the non-invasive examination of deeper tissue layers. This allows pathological changes to be detected at earlier stages, supports more precise monitoring of therapies, and advances the development of diagnostic procedures.

Life Sciences

The project opens up new possibilities for high-resolution microscopy and biological research, enabling detailed investigation of complex cellular and tissue structures as well as dynamic biological processes.

Endoscopy and Deep Tissue Imaging

Adaptive optical techniques make it possible to generate high-quality images even in highly scattering tissue. This creates new opportunities for minimally invasive examinations and next-generation imaging technologies in medical engineering.